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Gut Health and Fatigue Are Related

The association between gut problems and fatigue has been noted for years, but it wasn’t until very recently that researchers really started putting the pieces of the puzzle together, uncovering how abnormalities within the digestive system are related to fatigue and what can be done to heal both. Feeling chronically tired and also having digestive symptoms like abdominal pain, bloating, loose stools, diarrhea, alternating diarrhea and constipation, gas, and reflux means you likely have a “leaky gut” along with an overgrowth of “bad” gut microbial flora and too little healthy flora.[3,9]

Leaky gut is another term for increased intestinal permeability.  It is caused by a loosening of the tight junctions within the gut lining which form a barrier between the inside and outside of the digestive tract. It can be caused by any type of inflammatory process, including:

  • Infections with yeast, viruses, or bacteria
  • Long-term or very frequent use of antibiotics
  • Repeated use of pain-killers (NSAIDs) or alcohol
  • Long-standing psychological stress; extended exercise (athletes)
  • Food allergies or sensitivities, such as gluten sensitivity
  • insufficient intake of antioxidants

When any of these factors increase the permeability of the intestinal wall, unwanted bacteria, proteins, and other compounds can leak through. To deal with these foreign compounds, the body mounts an immune response, leading to more inflammation.

CFS and Gut Bacteria

Researchers have now found that if you have chronic fatigue syndrome (CFS), your body likely produces high levels of immune cells directed against the toxins given off by unhealthy gut bacteria—a sign of leaky gut and a cause of inflammation.[7] In fact, the severity of both chronic fatigue symptoms and digestive symptoms was found to directly correlate with the number of these immune cells directed against toxin-generating gut bacteria.

Probiotics are “friendly” microorganisms (typically bacteria or yeasts) that can live in the gastrointestinal tract or on other mucosal surfaces and have beneficial effects on human physiology and health. There are three general probiotic benefits which researchers believe may help in the treatment of leaky gut and chronic fatigue:

  • They increase the numbers of healthy bacteria that live in the gut while decreasing the unhealthy bacteria;
  • They improve the ability of the gut wall to act as a barrier to keep unwanted compounds out of the body;
  • They decrease your body’s own production of inflammation-producing compounds, lowering inflammation in the gut and throughout the body.[3]

Credit to: KATHLEEN JADE, ND  |  universityhealthnews.com

[1] Dansie EJ, Furberg H, Afari N, Buchwald D, Edwards K, Goldberg J, Schur E, Sullivan PF. Conditions comorbid with chronic fatigue in a population-based sample. Psychosomatics. 2012 Jan;53(1):44-50.

[2] Simrén M, Abrahamsson H, Svedlund J, Björnsson ES. Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: the impact of gender and predominant bowel pattern. Scand J Gastroenterol. 2001 May;36(5):545-52.

[3] Lakhan SE, Kirchgessner A. Gut inflammation in chronic fatigue syndrome. Nutr  Metab (Lond). 2010 Oct 12;7:79.

[4] Sullivan A, Nord CE, Evengård B. Effect of supplement with lactic-acid producing bacteria on fatigue and physical activity in patients with chronic fatigue syndrome. Nutr J. 2009 Jan 26;8:4.

[5] Singh PK, Chopra K, Kuhad A, Kaur IP. Role of Lactobacillus acidophilus loaded floating beads in chronic fatigue syndrome: behavioral and biochemical evidences. Neurogastroenterol Motil. 2012 Apr;24(4):366-e170.

[6] Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, Berardi JM, Logan AC. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009 Mar 19;1(1):6.

[7] Maes M, Mihaylova I, Leunis JC: Increased serum IgA and IgM against LPS of enterobacteria higher in chronic fatigue syndrome (CFS): Indication for the involvement of gram-negative bacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability. J Affect Disord. 2007;99(1):237–240.

[8] Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome(CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10.

[9] Logan AC, Venket Rao A, Irani D. Chronic fatigue syndrome: lactic acid bacteria may be of therapeutic value. Med Hypotheses. 2003 Jun;60(6):915-23.